Invitrogen™ NUDT5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554091

Catalog No. PIPA554091

Description

Immunogen sequence: SPAVCMDPGL SNCTIHIVTV TINGDDAENA RPKPKPGDGE FVEVISLPKN DLLQRLDALV AEEHLTVDAR VYSYALALKH ANAKPFEVPF LKF Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 90%.

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Specifications

• Antigen: NUDT5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUDT5
• Gene Alias: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; HSPC115; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix hydrolase 5; nudix motif 5; NUDIX5; nudix-type motif 5; NUDT5; YSA1; YSA1H; YSAH1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11164, 361274
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6AY63, Q9UKK9
• Gene Symbols: NUDT5
• Immunogen: Recombinant protein corresponding to Human NUDT5. Recombinant protein control fragment (Product #RP-92485).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov