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Invitrogen™ NUMB Monoclonal Antibody (T.873.4)
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Catalog No. PIMA514902
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100 μL
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Catalog No. Quantity
PIMA514902 100 μL
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Catalog No. PIMA514902 Supplier Invitrogen™ Supplier No. MA514902
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUMB
Applications Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone T.873.4
Concentration 352 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene Numb
Gene Accession No. P49757, Q2LC84, Q9QZS3
Gene Alias c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
Gene Symbols Numb
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Ala570 of human Numb protein.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18222, 29419, 8650
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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