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Invitrogen™ NUMB Monoclonal Antibody (T.873.4)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA514902

Catalog No. PIMA514902


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Description

Description

It is not recommended to aliquot this antibody.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NUMB
Monoclonal
352 μg/mL
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
P49757, Q2LC84, Q9QZS3
Numb
Synthetic peptide corresponding to residues surrounding Ala570 of human Numb protein.
100 μL
Primary
Human, Mouse, Rat, Monkey
Antibody
IgG
Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
T.873.4
Unconjugated
Numb
c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
Rabbit
Affinity chromatography
RUO
18222, 29419, 8650
-20°C
Liquid
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