NUMB Mouse anti-Human, Clone: OTI2E8, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF802143
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOProtein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
|Human recombit protein fragment corresponding to amino acids 1-365 of human NUMB produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|C14orf41, S171, c14_5527|
|-20° C, Avoid Freeze/Thaw Cycles|
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