NUMB Mouse anti-Human, Clone: OTI2F1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF802163

Catalog No. 50-166-5885

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

• Antigen: NUMB
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NUMB
• Gene Alias: C14orf41, S171, c14_5527
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8650
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2F1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P49757
• Gene Symbols: NUMB
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-365 of human NUMB produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1