NUMB Mouse anti-Human, Clone: OTI5A9, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA501561

Catalog No. 50-167-2697

Description

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

• Antigen: NUMB
• Classification: Monoclonal
• Concentration: 0.58 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P49757
• Gene Symbols: NUMB
• Immunogen: Full length human recombit protein of human NUMB produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5A9
• Conjugate: Unconjugated
• Gene: NUMB
• Gene Alias: C14orf41, S171, c14_5527
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8650
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid