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Invitrogen™ NUMB Polyclonal Antibody
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Catalog No. PIPA597209
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100 μL
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PIPA597209 100 μL
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Catalog No. PIPA597209 Supplier Invitrogen™ Supplier No. PA597209
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SQMVANVFGT AGHPQAAHPH QSPSLVRQQT FPHYEASSAT TSPFFKPPAQ HLNGSAAFNG VDDGRLASAD RHTEVPTGTC PVDPFEAQWA ALENKSKQRT NPSPTNPFSS DLQKTFEIEL; Positive Samples: HeLa, LO2, U-87MG, HT-1080, SW480, A-549, Rat liver; Cellular Location: Membrane, Peripheral membrane protein.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUMB
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Numb
Gene Accession No. P49757, Q2LC84, Q9QZS3
Gene Alias c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
Gene Symbols Numb
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 521-640 of human NUMB (NP_0037353).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18222, 29419, 8650
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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