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Invitrogen™ NUMBL Polyclonal Antibody
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Catalog No. PIPA5102585
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100 μL
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PIPA5102585 100 μL
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Catalog No. PIPA5102585 Supplier Invitrogen™ Supplier No. PA5102585
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NUMBL.

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUMBL
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Numbl
Gene Accession No. A1L1I3, O08919, Q9Y6R0
Gene Alias CAG3A; CTG3a; NBL; numb homolog (Drosophila)-like; numb homolog-like; NUMB like, endocytic adaptor protein; Numbl; NUMBLIKE; numb-like; numb-like protein; NUMBR; Numb-R; numb-related protein; TNRC23
Gene Symbols Numbl
Host Species Rabbit
Immunogen A synthesized peptide derived from human NUMBL(Accession Q9Y6R0), corresponding to amino acid residues L533-A583.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18223, 292732, 9253
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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