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Invitrogen™ NUMBL Polyclonal Antibody
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Catalog No. PIPA519655
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100 μg
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Catalog No. Quantity
PIPA519655 100 μg
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Catalog No. PIPA519655 Supplier Invitrogen™ Supplier No. PA519655
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with cow and human based on sequence homology.

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUMBL
Applications Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene Numbl
Gene Accession No. A1L1I3, O08919, Q9Y6R0
Gene Alias CAG3A; CTG3a; NBL; numb homolog (Drosophila)-like; numb homolog-like; NUMB like, endocytic adaptor protein; Numbl; NUMBLIKE; numb-like; numb-like protein; NUMBR; Numb-R; numb-related protein; TNRC23
Gene Symbols Numbl
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 200 - 300 of Human NUMBL.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18223, 292732, 9253
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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