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NUP107/Nuclear Pore Complex Proteins Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981576
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50-198-1576 100 μL
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Catalog No. 50-198-1576 Supplier Bioss Supplier No. BS11678R
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Description

Rabbit Polyclonal Antibody

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.

Specifications

Antigen NUP107/Nuclear Pore Complex Proteins
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NUP107
Gene Accession No. P57740
Gene Alias 107 kDa nucleoporin; AW541137; BcDNA:LD18761; BOS_5256; C76801; CG6743; CG6743 gene product from transcript CG6743-RA; CG6743-PA; Dmel\CG6743; Dmel_CG6743; dmNup107; NPHS11; Nuclear pore complex protein Nup107; nucleoporin 107; nucleoporin 107kD; nucleoporin 107kDa; Nucleoporin Nup107; Nup 107; Nup107; Nup107-PA; Nup170; NUP84; p105
Gene Symbols NUP107
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Nuclear pore complex protein Nup107.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57122
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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