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Invitrogen™ NUP107 Polyclonal Antibody
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Catalog No. PIPA520562
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100 μg
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Catalog No. Quantity
PIPA520562 100 μg
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Catalog No. PIPA520562 Supplier Invitrogen™ Supplier No. PA520562
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Description

Rabbit Polyclonal Antibody

A suggested positive control is A549 cell lysate. PA5-20562 can be used with blocking peptide PEP-0682.

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUP107
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NUP107
Gene Accession No. P52590, P57740, Q8BH74
Gene Alias 107 kDa nucleoporin; AW541137; BcDNA.LD18761; BcDNA:LD18761; C76801; CG6743; CG6743-PA; Dmel\CG6743; Dmel_CG6743; dmNup107; NPHS11; nuclear pore complex; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup107-like protein; nucleoporin 107; Nucleoporin 107kD; nucleoporin 107kDa; nucleoporin Nup107; Nup; Nup 107; nup107; Nup107-PA; Nup170; NUP84; p105
Gene Symbols NUP107
Host Species Rabbit
Immunogen A 20 amino acid peptide from near the center of human NUP107.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103468, 116555, 57122
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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