Invitrogen™ NUP160 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101723

Catalog No. PIPA5101723

Description

Antibody detects endogenous levels of total NUP160.

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-160 is part of the hetero-oligomeric complex that also contains NUP107, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP160 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP160 may be an important drug target in HIV treatment. Multiple isoforms of NUP160 are known to exist.

Specifications

• Antigen: NUP160
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUP160
• Gene Alias: 160 kDa nucleoporin; 160kDa; 2810011M03Rik; AA414952; AU020188; Gene trap locus 1-13 protein; gene trap locus-13; Gtl1-13; Gtl13; GTL-13; KIAA0197; mKIAA0197; Nuclear pore complex protein Nup160; nucleoporin 160; nucleoporin 160kD; nucleoporin 160kDa; nucleoporin Nup160; NUP120; Nup160
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23279, 59015
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q12769, Q9Z0W3
• Gene Symbols: NUP160
• Immunogen: A synthesized peptide derived from human NUP160(Accession Q12769), corresponding to amino acid residues E425-A475.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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