Invitrogen™ NUP98 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517406

Catalog No. PIPA517406

Description

It is not recommended to aliquot this antibody.

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Specifications

• Antigen: NUP98
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P49793, P52948, Q6PFD9
• Gene Symbols: NUP98, nup98.L
• Immunogen: Synthetic peptide corresponding to residues surrounding Leu205 of human NUP98.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey, Bovine, Frog
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: NUP98
• Gene Alias: 4732457F17; 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; adir2; AI849286; GLFG-repeat containing nucleoporin; im:7151238; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96; nucleoporin 98; nucleoporin 98 and 96 precursor; nucleoporin 98 L homeolog; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; Nup96; NUP98; nup98.L; NUP98/PHF23 fusion 2 protein; Nup98-Nup96; OTTHUMP00000013954; zgc:113968; zgc:63593; zgc:63593 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 269966, 446233, 476822, 4928, 540004, 81738
• Content And Storage: -20°C
• Form: Liquid