Invitrogen™ NUP98 Polyclonal Antibody

Catalog No.	Quantity
PIPA595227	100 μg

Catalog No. PIPA595227 Supplier Invitrogen™ Supplier No. PA595227

Description

Rabbit Polyclonal Antibody

Human NUP98 shares 95% and 94% amino acid (aa) sequence identity with mouse and rat NUP98, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human K562 whole cell, human MCF-7 whole cell, human COLO320 whole cell, human HepG2 whole cell, human Hacat whole cell, monkey COS-7 whole cell, rat NRK whole cell, mouse lung tissue, mouse NIH/3T3 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Specifications

• Antigen: NUP98
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5mg BSA and 0.01mg sodium azide
• Gene: NUP98
• Gene Accession No.: P49793, P52948, Q6PFD9
• Gene Alias: 4732457F17; 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; adir2; AI849286; GLFG-repeat containing nucleoporin; im:7151238; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96; nucleoporin 98; nucleoporin 98 and 96 precursor; nucleoporin 98 L homeolog; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; Nup96; NUP98; nup98.L; NUP98/PHF23 fusion 2 protein; Nup98-Nup96; OTTHUMP00000013954; zgc:113968; zgc:63593; zgc:63593 protein
• Gene Symbols: NUP98
• Host Species: Rabbit
• Immunogen: E.coli-derived human NUP98 recombinant protein (Position: H549-F880).
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 269966, 4928, 81738
• Target Species: Human, Mouse, Rat, Monkey
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG