Invitrogen™ NUP98 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121733

Catalog No. PIPA5121733

Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Specifications

• Antigen: NUP98
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUP98
• Gene Alias: 4732457F17; 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; adir2; AI849286; GLFG-repeat containing nucleoporin; im:7151238; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96; nucleoporin 98; nucleoporin 98 and 96 precursor; nucleoporin 98 L homeolog; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; Nup96; NUP98; nup98.L; NUP98/PHF23 fusion 2 protein; Nup98-Nup96; OTTHUMP00000013954; zgc:113968; zgc:63593; zgc:63593 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 269966, 4928
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P52948, Q6PFD9
• Gene Symbols: NUP98
• Immunogen: Gln629-Pro894 (Accession P52948), with N-terminal His Tag.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG