Nurr1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA14519

Catalog No. APP4519

Description

PA1-4519 detects Nurr1 in human, rat, and mouse samples. PA1-4519 has been successfully used in Western blot and Immunohistochemistry procedures. This antibody is specific for the ∽70 kDa protein representing Nurr1. PA1-4519 immunogen is a synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein.

The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.

Specifications

• Antigen: Nurr1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR4A2
• Gene Alias: HZF3, Hzf-3, Immediate-early response protein NOT, intermediate-early receptor protein, NGFI-B, NGFI-B beta, NGFI-B/nur77 beta-type transcription factor homolog, NOT, NR4A2, Nuclear orphan receptor HZF-3, nuclear receptor related 1, nuclear receptor subfamily 4 group A member 2, nuclear receptor subfamily 4 group A member 2 variant TINUR, nuclear receptor subfamily 4 group A member 2 variant NURR1a, nuclear receptor subfamily 4 group A member 2 variant NURR1b, nuclear receptor subfamily 4 group A member 2 variant NURR1c, nuclear receptor subfamily 4 group A member 2 variant NURR2c, nuclear receptor subfamily 4, group A, member 2, nur related protein 1, nur related protein-1, human homolog of, Nurr1, NUR-related factor 1, orphan nuclear receptor NR4A2, orphan nuclear receptor NURR1, Regenerating liver nuclear receptor 1, RNR1, RNR-1, SL-322, T-cell nuclear receptor NOT, TINOR, TINUR, transcriptionally inducible nuclear receptor related 1, transcriptionally-inducible nuclear receptor
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18227, 4929, 54278
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P43354, Q06219, Q07917
• Gene Symbols: NR4A2
• Immunogen: Synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov