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Tocris Bioscience™ NVP 2
GREENER_CHOICE

Catalog No. 65355
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective ATP-competitive CDK9 inhibitor

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

Specifications

Chemical Name or Material 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
CAS 1263373-43-8
Quantity 5 mg
Molecular Formula C27H37ClN6O2
Formula Weight 513.07
Product Type Inhibitor
Purity 97%
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