Tocris™ NVP ADW 742

ATP-competitive inhibitor of IGF1R

Manufacturer: Tocris™ 5247/50

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Catalog No. 52-475-0

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For Research Use Only


    Inhibitors NVP ADW 742
    Purity >99
    Molecular Weight 453.58
    Quantity 50mg
    Product Type NVP ADW 742

    ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2µM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5µM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).

    • Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    • Formula: C28H31N5O
    • CAS Number: 475488-23-4
    • Solubility: Soluble to 50mM in DMSO and to 10mM in ethanol
    • Purity: >99

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