ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2µM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5µM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).
Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS Number: 475488-23-4
Solubility: Soluble to 50mM in DMSO and to 10mM in ethanol
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