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  5. Tocris Bioscience™ NVP-TNKS656

Tocris Bioscience™ NVP-TNKS656
SDP

Catalog No. 891350 Shop All R&D Systems Products
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89-135-0 50 mg
89-131-0 10 mg
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Catalog No. 89-135-0 Supplier Tocris Bioscience™ Supplier No. 8913/50
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Description

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells

NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC50 values are 7.8 and 8.2 for TNKS1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.

Specifications

Chemical Name or Material N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide
CAS 1419949-20-4
Quantity 50 mg
Target Tankyrase Inhibitors
Molecular Formula C27H34N4O5
Purity 98%
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