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Nystatin, MP Biomedicals™

Catalog No. MP021945345 Shop All MP Biomedicals, Inc Products
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Quantity:
500 kU

Description

Nystatin is an antifungal antibiotic obtained from Streptomyces noursei.

Nystatin A is closely related to Amphotericin B. Each is a macrocyclic lactone containing a ketal ring, an all-trans polyene system, and a mycosamine (3-amino-3-deoxyrhamnose) moiety. Nystatin probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components. It is absorbed very sparingly following oral administration. Most of the orally administered nystatin is passed unchanged in the stool.

  • Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels.
  • It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.
  • It is known to be a mixture, but the composition has not been completely elucidated.
  • Working concentration is 50mg/L for yeasts and fungi.
    TRUSTED_SUSTAINABILITY

    Chemical Identifiers

    CAS 1400-61-9
    Molecular Formula C47H75NO17
    Molecular Weight (g/mol) 926.107
    InChI Key VQOXZBDYSJBXMA-AWCIUYGFSA-N
    Synonym Mycostatin; Fungicidin
    PubChem CID 133640190
    IUPAC Name (1S,3R,6Z,18S,19R,20S,21S,25S,27S,29S,32R,33S,35S,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carb
    SMILES CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

    Specifications

    Physical Form Powder
    Absorbance 290, 305, 320 ± 2nm (max (ethanol))
    pH 6 to 8 (3% aq. soln.)
    Melting Point >160°C (literature)
    Loss on Drying <8%
    Quantity 500 kU
    Validated Application Cell Culture
    Solubility Information Very slightly soluble in water (effective as a suspension); slightly to sparingly soluble in alcohol, in methanol, in n-propyl alcohol, and in n-butyl alcohol; insoluble in chloroform, in ether, and in benzene.
    Formula Weight 926.11g/mol
    Grade Cell Culture

    Safety and Handling

    Recommended Storage Store at + 4°C. Protect from light.
    WARNING: Cancer - www.P65Warnings.ca.gov
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