Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. MP021945345

Nystatin, MP Biomedicals™

Catalog No. MP021945345 Shop All MP Biomedicals, Inc Products
Change view
Click to view available options
Quantity:
500 kU
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
MP021945345 500 kU
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. MP021945345 Supplier MP Biomedicals, Inc Supplier No. 02194534.5
Only null left
Add to Cart
Add to Cart

Description

Nystatin is an antifungal antibiotic obtained from Streptomyces noursei.

Nystatin A is closely related to Amphotericin B. Each is a macrocyclic lactone containing a ketal ring, an all-trans polyene system, and a mycosamine (3-amino-3-deoxyrhamnose) moiety. Nystatin probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components. It is absorbed very sparingly following oral administration. Most of the orally administered nystatin is passed unchanged in the stool.

  • Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels.
  • It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.
  • It is known to be a mixture, but the composition has not been completely elucidated.
  • Working concentration is 50mg/L for yeasts and fungi.
    TRUSTED_SUSTAINABILITY

    Chemical Identifiers

    CAS 1400-61-9
    Molecular Formula C47H75NO17
    Molecular Weight (g/mol) 926.107
    InChI Key VQOXZBDYSJBXMA-AWCIUYGFSA-N
    Synonym Mycostatin; Fungicidin
    PubChem CID 133640190
    IUPAC Name (1S,3R,6Z,18S,19R,20S,21S,25S,27S,29S,32R,33S,35S,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carb
    SMILES CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

    Specifications

    Physical Form Powder
    Absorbance 290, 305, 320 ± 2nm (max (ethanol))
    pH 6 to 8 (3% aq. soln.)
    Melting Point >160°C (literature)
    Loss on Drying <8%
    Quantity 500 kU
    Validated Application Cell Culture
    Solubility Information Very slightly soluble in water (effective as a suspension); slightly to sparingly soluble in alcohol, in methanol, in n-propyl alcohol, and in n-butyl alcohol; insoluble in chloroform, in ether, and in benzene.
    Formula Weight 926.11g/mol
    Grade Cell Culture

    Safety and Handling

    Recommended Storage Store at + 4°C. Protect from light.
    WARNING: Cancer - www.P65Warnings.ca.gov
    Product Title
    Select an issue

    By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.