Invitrogen™ OAS3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559539

Catalog No. PIPA559539

Description

Immunogen sequence: TWDLGNGAAW HWDLLAQEAA SCYDHPCFLR GMGDPVQSWK GPGLPRAGCS GLGHPIQLDP NQKTPENSKS LNAVYPRAGS KPPSCP Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 27%.

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Specifications

• Antigen: OAS3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OAS3
• Gene Alias: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2',5'-oligoadenylate synthetase-like 10; 2'-5' oligoadenylate synthetase 3; 2'-5' oligoadenylate synthetase-like 10; 2-5A synthase 3; 2-5A synthetase 3; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; Oas3; oasl10; P/OKcl.4; p100; p100 OAS; p100OAS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4940
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6K5
• Gene Symbols: OAS3
• Immunogen: Recombinant protein corresponding to Human OAS3. Recombinant protein control fragment (Product #RP-97705).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG