Learn More
Invitrogen™ Occludin Monoclonal Antibody (OC-3F10)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 331500

Description
Occludin Monoclonal Antibody for Western Blot, ICC/IF, ELISA
Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
Specifications
Occludin | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.1% sodium azide; pH 7.4 | |
Q16625, Q28269, Q61146, Q6P6T5 | |
OCLN | |
GST fusion protein consisting of the C-terminal region (~150aa) of human occludin. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Canine | |
Antibody | |
IgG1 κ |
ELISA, Western Blot, Immunocytochemistry | |
OC-3F10 | |
Unconjugated | |
OCLN | |
AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein | |
Mouse | |
Protein A | |
RUO | |
100506658, 18260, 403844, 83497 | |
-20°C | |
Liquid |
Safety and Handling
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.