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OCLN Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501570057
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Catalog No. Quantity
50-157-0057 100 μL
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Catalog No. 50-157-0057 Supplier Bethyl Laboratories, Inc Supplier No. A305297A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Dog and Orangutan

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Specifications

Antigen OCLN
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene OCLN
Gene Accession No. Q16625
Gene Alias BLCPMG, phosphatase 1, regulatory subunit 115, PPP1R115, tight junction protein occludin, tight junction protein occludin TM4 minus
Gene Symbols OCLN
Host Species Rabbit
Immunogen Between 472 and 522
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506658
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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