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Invitrogen™ OGG1 Polyclonal Antibody
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Catalog No. PIPA518747
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100 μg
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Catalog No. Quantity
PIPA518747 100 μg
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Catalog No. PIPA518747 Supplier Invitrogen™ Supplier No. PA518747
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen OGG1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene OGG1
Gene Accession No. O08760, O15527, O70249
Gene Alias 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; Mmh; MUTM; N-glycosylase/DNA lyase; OGG1; OGG1 type 1f; OGH1
Gene Symbols OGG1
Host Species Goat
Immunogen Synthetic peptide sequence (HPKTSQAKGPSPLANK) corresponding to the internal amino acids of OGG1 (aa 282-297).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18294, 4968, 81528
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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