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Invitrogen™ OGG1 Polyclonal Antibody
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Catalog No. PIPA598026
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100 μg
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Catalog No. Quantity
PIPA598026 100 μg
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Catalog No. PIPA598026 Supplier Invitrogen™ Supplier No. PA598026
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Description

Rabbit Polyclonal Antibody

OGG1 Polyclonal Antibody for Western Blot, IHC (P), ELISA

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen OGG1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene OGG1
Gene Accession No. O15527
Gene Alias 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; Mmh; MUTM; N-glycosylase/DNA lyase; OGG1; OGG1 type 1f; OGH1
Gene Symbols OGG1
Host Species Rabbit
Immunogen Recombinant Human N-glycosylase/DNA lyase protein (1-345AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4968
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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