Invitrogen™ OLFM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587397

Catalog No. PIPA587397

Description

Immunogen sequence: IEVLDRRTQR DLQYVEKMEN QMKGLESKFK QVEESHKQHL ARQFKAIKAK MDELRPLIPV LEEYKADAKL VLQFKEEVQN LTSVLNELQE EIGAYDYDEL QSRVSNLEER LRACMQKLAC GKLTGISDPV T; Positive Samples: Mouse brain, MCF7, A-549, SW480; Cellular Location: Cell junction, Cell projection, Endoplasmic reticulum, Perikaryon, axon, synapse.

The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

Specifications

• Antigen: OLFM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OLFM1
• Gene Alias: 1B426B; AMY; AW742568; D2Sut1e; neuroblastoma protein; neuronal olfactomedin-related ER localized protein; Noe1; Noel; Noel1; Noelin; Noelin 1; Noelin 2; NOELIN1; OlfA; olfactomedin 1; olfactomedin related ER localized protein; olfactomedin-1; OLFM1; Pancortin; pancortin 1; Pancortin 1-4; Pancortin3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10439, 56177
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.35 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O88998, Q99784
• Gene Symbols: OLFM1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 90-220 of human OLFM1 (NP_0550941).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov