Invitrogen™ Oligomer A11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ AHB0052

Catalog No. AHB0052

Description

This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35. Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.

Specifications

• Antigen: Oligomer A11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: INS
• Gene Alias: Antioligomer A11; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2-rs1; Insulin; insulin 1; Insulin A chain; Insulin B chain; insulin I; insulin-1; Insulin-1 A chain; Insulin-1 B chain; IRDN; MODY10; preproinsulin; proinsulin
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 16333, 24505, 3630
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Green Features: Responsibly packaged

• Applications: Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P01308, P01322, P01325
• Gene Symbols: INS, Ins1
• Immunogen: Synthetic molecular mimic of soluble oligomers.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG