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  5. Tocris Bioscience™ Omipalisib

Tocris Bioscience™ Omipalisib
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Catalog No. 679250
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Catalog No. Quantity
67-925-0 50 mg
67-921-0 10 mg
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Catalog No. 67-925-0 Supplier Tocris Bioscience™ Supplier No. 6792/50
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Description

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.

Specifications

Chemical Name or Material 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Synonym GSK2126458
Quantity 50 mg
Molecular Formula C25H17F2N5O3S
Formula Weight 505.5
Product Type Inhibitor
Purity 98%
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