Invitrogen™ Oncostatin M Monoclonal Antibody (17001)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523810

Catalog No. PIMA523810

Description

In ELISAs, this antibody does not cross-react with recombinant human (rh) IL-6, rhIL-11, rhCNTF, or rhLIF. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

Specifications

• Antigen: Oncostatin M
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P13725
• Gene Symbols: OSM
• Immunogen: E. coli-derived recombinant human Oncostatin M/OSM Ala26-Arg234.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Neutralization, Western Blot
• Clone: 17001
• Conjugate: Unconjugated
• Gene: OSM
• Gene Alias: MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 5008
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized