Invitrogen™ Oncostatin M Polyclonal Antibody

Catalog No.	Quantity
PIPA547022	100 μg

Catalog No. PIPA547022 Supplier Invitrogen™ Supplier No. PA547022

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human OSM is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

Specifications

• Antigen: Oncostatin M
• Applications: Immunohistochemistry (Frozen), Neutralization, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: OSM
• Gene Accession No.: P53347
• Gene Alias: MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
• Gene Symbols: OSM
• Host Species: Goat
• Immunogen: E. coli-derived recombinant mouse OSM Ala24-Arg206.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18413
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov