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Tocris Bioscience™ ONO 6818
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Catalog No. 565110
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56-511-0 10 mg
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Description

High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active

ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Specifications

Chemical Name or Material 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
CAS 208848-19-5
Quantity 10 mg
Target Synthetic Elastase Inhibitors
Molecular Formula C23H28N6O4
Formula Weight 452.51
Purity >98%
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