Invitrogen™ OPHN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551775

Catalog No. PIPA551775

Description

Immunogen sequence: RVTARRHKPI TISKRLLRER TVFYTSSLDE SEDEIQHQTP NGTITSSIEP PKPPQHPKLP IQRSGETDPG RKSPSRPILD GKLEPCPEVD VGKLVSRLQD GGTKITPK Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.

Specifications

• Antigen: OPHN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OPHN1
• Gene Alias: ARHGAP41; C130037N19Rik; mental retardation, X-linked 60; MRX60; oligophrenin 1; oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein; Ophn1; Opn1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4983
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60890
• Gene Symbols: OPHN1
• Immunogen: Recombinant protein corresponding to Human OPHN1. Recombinant protein control fragment (Product #RP-92171).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG