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Invitrogen™ Optineurin Polyclonal Antibody
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Catalog No. PIPA595954
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100 μL
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PIPA595954 100 μL
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Catalog No. PIPA595954 Supplier Invitrogen™ Supplier No. PA595954
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII; Positive Samples: HeLa, OVCAR3, A-549, Mouse liver, Mouse heart; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Recycling endosome, autophagosome, perinuclear region, trans-Golgi network.

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Optineurin
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene OPTN
Gene Accession No. Q8K3K8, Q96CV9
Gene Alias 14.7K-interacting protein 2; 4930441O07Rik; Ag9 C5; ALS12; E3-14.7K-interacting protein; FIP 2; FIP2; FIP-2; FIP-2-like protein; GLC1E; HIP 7; HIP7; HIP-7; Huntingtin interacting protein L; huntingtin yeast partner L; Huntingtin-interacting protein 7; huntingtin-interacting protein L; HYPL; NEMO-related protein; NRP; Optic neuropathy-inducing protein; optineurin; Optn; TFIIIA IntP; TFIIIA-IntP; transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains; Uban
Gene Symbols OPTN
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_0688152).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10133, 71648
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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