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Invitrogen™ ORC1 Monoclonal Antibody (TK 1/2)
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Catalog No. PIMA190545
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100 μg
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Catalog No. Quantity
PIMA190545 100 μg
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Catalog No. PIMA190545 Supplier Invitrogen™ Supplier No. MA190545
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Description

Mouse Monoclonal Antibody

MA1-90545 detects ORC1 from Xenopus laevis samples.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ORC1
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone TK 1/2
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene orc1.L
Gene Accession No. 0
Gene Alias AA545195; HS; HSORC1; MmORC1; orc1; orc1.L; Orc1l; origin recognition complex protein 1; origin recognition complex subunit 1; origin recognition complex subunit 1 L homeolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1-like; PARC1; Replication control protein 1; XELAEV_18023178mg; xorc1
Gene Symbols orc1.L
Host Species Mouse
Immunogen Recombinant full length protein (Xenopus laevis).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 398063
Target Species Frog
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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