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ORC1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA523390
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100 μg
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Catalog No. Quantity
PIPA523390 100 μg
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Catalog No. PIPA523390 Supplier Thermo Scientific Supplier No. PA523390

Description

Rabbit Polyclonal Antibody

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ORC1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Orc1
Gene Accession No. Q13415, Q9Z1N2
Gene Alias AA545195; HS; HSORC1; MmORC1; orc1; orc1.L; Orc1l; origin recognition complex protein 1; origin recognition complex subunit 1; origin recognition complex subunit 1 L homeolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1-like; PARC1; Replication control protein 1; XELAEV_18023178mg; xorc1
Gene Symbols Orc1
Host Species Rabbit
Immunogen A portion of amino acids 170 to 220 of human ORC1L
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18392, 4998
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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