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ORC1L Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988739
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50-198-8739 100 μL
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Catalog No. 50-198-8739 Supplier Bioss Supplier No. BS8998R
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Description

Rabbit Polyclonal Antibody

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.

Specifications

Antigen ORC1L
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Orc1
Gene Accession No. Q13415
Gene Alias AA545195; HS; HSORC1; MmORC1; ORC1; orc1.L; Orc1l; origin recognition complex protein 1; Origin recognition complex subunit 1; origin recognition complex subunit 1 L homeolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1-like; PARC1; Replication control protein 1; XELAEV_18023178mg; xorc1
Gene Symbols Orc1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ORC1L/ORC1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4998
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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