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ORP3 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501568035
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50-156-8035 20 μL
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Catalog No. 50-156-8035 Supplier Bethyl Laboratories, Inc Supplier No. A304557AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).

Specifications

Antigen ORP3
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene OSBPL3
Gene Accession No. Q9DBS9, Q9H4L5
Gene Alias KIAA0704, ORP3, ORP-3, OSBP3, OSBP-related protein 3, oxysterol binding protein-like 3
Gene Symbols OSBPL3
Host Species Rabbit
Immunogen Between 456 and 506
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26031, 71720
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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