Invitrogen™ OTOF Polyclonal Antibody

Catalog No.	Quantity
PIPA552935	100 μL

Catalog No. PIPA552935 Supplier Invitrogen™ Supplier No. PA552935

Description

Rabbit Polyclonal Antibody

Immunogen sequence: PIIVIEIYDQ DSMGKADFMG RTFAKPLVKM ADEAYCPPRF PPQLEYYQIY RGNATAGDLL AAFELLQIGP AGKADLPPIN GPVDVDRGPI MPVPMGIRPV LSKYRVEVLF WGLRDLKRVN L Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.

Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.

Specifications

• Antigen: OTOF
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: OTOF
• Gene Accession No.: Q9HC10
• Gene Alias: AUNB1; DFNB6; DFNB9; FER1L2; fer-1-like family member 2; fer-1-like protein 2; NSRD9; Otof; Otoferlin
• Gene Symbols: OTOF
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human OTOF. Recombinant protein control fragment (Product #RP-90139).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9381
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG