Invitrogen™ OTUB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558684

Catalog No. PIPA558684

Description

Immunogen sequence: AAEEPQQQKQ EPLGSDSEGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPD Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

The product of this gene is a member of the OTU superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: OTUB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OTUB1
• Gene Alias: AI850305; Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250; EMBL:AAI66771.1}; FLJ20113; FLJ40710; hOTU1; HSPC263; hypothetical protein LOC540984; MGC111158; MGC4584; OTB1; OTU deubiquitinase, ubiquitin aldehyde binding 1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250; OTU1; OTUB1; otub1 {ECO:0000312; otubain 1; otubain-1; otubain-1 {ECO:0000250; OTU-domain Ubal-binding 1; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250; UniProtKB:Q7TQI3}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107260, 293705, 55611
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: B2RYG6, Q7TQI3, Q96FW1
• Gene Symbols: OTUB1
• Immunogen: Recombinant protein corresponding to Human OTUB1. Recombinant protein control fragment (Product #RP-95850).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG