Invitrogen™ OTUB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120082

Catalog No. PIPA5120082

Description

Positive test controls include: 293T, Mouse intestine, Mouse liver. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: ERLELSVLYK EYAEDDNIYQ QKIKDLHKKY SYIRKTRPDG NCFYRAFGFS HLEALLDDSK ELQRFKAVSA KSKEDLVSQG FTEFTIEDFH NTFMDLIEQV E.

The product of this gene is a member of the OTU superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: OTUB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OTUB1
• Gene Alias: AI850305; Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250; EMBL:AAI66771.1}; FLJ20113; FLJ40710; hOTU1; HSPC263; hypothetical protein LOC540984; MGC111158; MGC4584; OTB1; OTU deubiquitinase, ubiquitin aldehyde binding 1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250; OTU1; OTUB1; otub1 {ECO:0000312; otubain 1; otubain-1; otubain-1 {ECO:0000250; OTU-domain Ubal-binding 1; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250; UniProtKB:Q7TQI3}
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107260, 55611
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.09 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q7TQI3, Q96FW1
• Gene Symbols: OTUB1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human OTUB1 (NP_060140.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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