Invitrogen™ OTUB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521402

Catalog No. PIPA521402

Description

Recommended positive controls: HeLa, HepG2, mouse brain, rat brain. Predicted reactivity: Mouse (100%), Rat (100%), Dog (99%), Pig (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The product of this gene is a member of the OTU superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: OTUB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OTUB1
• Gene Alias: AI850305; Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250; EMBL:AAI66771.1}; FLJ20113; FLJ40710; hOTU1; HSPC263; hypothetical protein LOC540984; MGC111158; MGC4584; OTB1; OTU deubiquitinase, ubiquitin aldehyde binding 1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250; OTU1; OTUB1; otub1 {ECO:0000312; otubain 1; otubain-1; otubain-1 {ECO:0000250; OTU-domain Ubal-binding 1; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250; UniProtKB:Q7TQI3}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107260, 293705, 55611
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: B2RYG6, Q7TQI3, Q96FW1
• Gene Symbols: OTUB1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 149 of OTUB1 (Uniprot ID#Q96FW1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov