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Invitrogen™ OTUD7B Polyclonal Antibody
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Catalog No. PIPA540934
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100 μL
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PIPA540934 100 μL
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Catalog No. PIPA540934 Supplier Invitrogen™ Supplier No. PA540934
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Description

Rabbit Polyclonal Antibody

Peptide sequence: WKGGKEEAAG DGPVSEKPPA ESVGNGGSKY SQEVMQSLSI LRTAMQGEGK Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%.

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen OTUD7B
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene OTUD7B
Gene Accession No. Q6GQQ9
Gene Alias 2900060B22Rik; 4930463P07Rik; AI462125; cellular zinc finger anti-NF-kappaB Cezanne; cellular zinc finger anti-NF-kappa-B protein; CEZANNE; OTU deubiquitinase 7B; OTU domain containing 7B; OTU domain-containing protein 7B; OTUD7B; RGD1308111; Trabid2; TRAF binding domain containing 2; Za20d1; Zinc finger A20 domain-containing protein 1; zinc finger protein Cezanne; zinc finger, A20 domain containing 1
Gene Symbols OTUD7B
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human ZA20D1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56957
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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