OTUD7B Mouse anti-Human, Clone: OTI2E2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527168
DescriptionNegative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ft.Lys-48 ft.-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ft.Lys-11 ft., ft.Lys-48 ft. or ft.Lys-63 ft.- linked polyubiquitin chains. In vitro, has preference for ft.Lys- 11 ft.-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne, OTUD7B, ZA20D1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 449-729 of OTUD7B produced in E.coli|
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