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OTUD7B Mouse anti-Human, Clone: OTI2E2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527168

Catalog No. PIMA527168


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Description

Description

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates  ft.Lys-48 ft.-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward  ft.Lys-11 ft.,  ft.Lys-48 ft. or  ft.Lys-63 ft.- linked polyubiquitin chains. In vitro, has preference for  ft.Lys- 11 ft.-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
Specifications

Specifications

OTUD7B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q6GQQ9
OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne, OTUD7B, ZA20D1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
56957
Western Blot
OTI2E2
Unconjugated
OTUD7B
Liquid
OTUD7B
Human recombit protein fragment corresponding to amino acids 449-729 of OTUD7B produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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