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Invitrogen™ Ovine IL-12 p70 ELISA Kit Non-distribution product as customer accommodation.

Ovine IL-12 p70 quantitates ovine IL-12 p70 in serum, plasma, supernatant.

$491.00 - $2205.00

Specifications

Regulatory Status Research Use Only
Storage Requirements 2°C to 8°C
Target IL-12 p70
Product Type ELISA
Kit Contents Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
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Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
ESH2RBX5 Non-distribution product as customer accommodation.
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Invitrogen™
ESH2RBX5
5 x 96 Tests
Each for $2,205.00
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ESH2RB Non-distribution product as customer accommodation.
View Documents
Invitrogen™
ESH2RB
96 Tests
Each for $491.00
Add to cart
 
Description

Description

Ovine IL-12 p70 quantitates ovine IL-12 p70 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant ovine IL-12 p70.

Interleukin-12 (IL-12) is a heterodimeric 70 kDa cytokine composed of two covalently linked, glycosylated chains with molecular weights of 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-g) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. Studies have established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-g and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation. Recombinant mouse IL-12 p70 is produced in baculovirus-infected insect cells as an authentic heterodimer of precursor p35 and p40 subunits using a dual promoter expression system. IL-12 p70 is distinct from other available forms of the protein in that it is expressed as a true heterodimer, as opposed to a single-chain, pseudo-heterodimer in which the subunits are joined by an artificial linker. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. Human and mouse IL-12 p40 share about 70% amino acid sequence homology.
Specifications

Specifications

Research Use Only
IL-12 p70
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
4 hr 45 min
Serum, Plasma, Supernatant
2°C to 8°C
ELISA
2.5 pg/mL
1 hr 20 min
Plasma, 50 µL; Supernatant, 50 µL; Serum, 50 µL
SDS
Product Certifications
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