Invitrogen™ OX40L Polyclonal Antibody, PE

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA546885

Catalog No. PIPA546885

Description

In Western blots, approximately 5% cross-reactivity with recombinant human (rh) OX40 Ligand, rhLIGHT, recombinant mouse (rm) Fas Ligand and less than 1% cross-reactivity with rmTNF- alpha, rhGITR Ligand, rhTRANCE, and rhVEGI is observed.

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

Specifications

• Antigen: OX40L
• Classification: Polyclonal
• Formulation: Buffered saline solution with BSA and 0.09% sodium azide
• Gene Accession No.: P43488
• Gene Symbols: Tnfsf4
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse OX40 Ligand/TNFSF4 Gln49-Leu198.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry
• Conjugate: PE
• Gene: Tnfsf4
• Gene Alias: Ath1; Ath-1; atherosclerosis 1; CD134 ligand; CD134L; CD252; glycoprotein Gp34; GP34; OX40 antigen ligand; OX40 ligand; OX40L; OX-40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tax-transcriptionally activated glycoprotein 1 ligand; TNFSF4; TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1; Txgp1l
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22164
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov