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Invitrogen™ OXPAT Polyclonal Antibody
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Catalog No. PA146215
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100 μL
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PA146215 100 μL
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Catalog No. PA146215 Supplier Invitrogen™ Supplier No. PA146215
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Description

Rabbit Polyclonal Antibody

The target sequence has 94% sequence homology with sheep and porcine and 84% sequence homology with rat. Suggested positive control: human and mouse heart lysate.

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
TRUSTED_SUSTAINABILITY

Specifications

Antigen OXPAT
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Plin5
Gene Accession No. A6QLL0, Q00G26, Q8BVZ1
Gene Alias 2310076L09Rik; AI415325; AW109675; lipid droplet associated protein; lipid droplet-associated protein PAT-1; Lipid storage droplet protein 5; LSDA5; LSDP5; Mldp; Myocardial LD protein; Oxpat; Pat1; PAT-1; perilipin 5; perilipin-5; Plin5
Gene Symbols Plin5
Host Species Rabbit
Immunogen A synthetic peptide made to a region of the human OXPAT protein, within residues 300-400.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100142670, 440503, 531199, 66968
Target Species Bovine, Human, Mouse, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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