Invitrogen™ Oxycodone Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA175335

Catalog No. PIPA175335

Description

Working Concentration: 1/8K. Sensitivity: 10 ng/mL Oxycodone produces 39% inhibition in a competitive ELISA employing Oxycodone (N) polyclonal antibody.

Oxycodone is a semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=5284603].

Specifications

• Antigen: Oxycodone
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Host Species: Sheep
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Conjugate: Unconjugated
• Gene Alias: C18H21NO4; Dihydrohydroxycodeinone; Dihydrone; Dihydroxycodeinone; Oxycodeinone; Oxycontin
• Immunogen: Oxycodone(N)-BSA.
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical