Invitrogen™ P-cadherin Polyclonal Antibody

Catalog No.	Quantity
PIPA5110641	100 μL

Catalog No. PIPA5110641 Supplier Invitrogen™ Supplier No. PA5110641

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YNGVVAYSIH SQEPKDPHDL MFTIHRSTGT ISVISSGLDR EKVPEYTLTI QATDMDGDGS TTTAVAVVEI LDANDNAPMF DPQKYEAHVP ENAVGHEVQR LTVTDLDAPN SPAWRATYLI MGGDDGDHFT ITTHPE Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 90%.

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Specifications

• Antigen: P-cadherin
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Cdh3
• Gene Accession No.: P22223
• Gene Alias: AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
• Gene Symbols: Cdh3
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human P-cadherin. Recombinant protein control fragment (Product #RP-100914).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1001
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG