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P-cadherin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 137731AP150UL

Encompass_Preferred

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Catalog No. 50-172-8998


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Description

Description

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
Specifications

Specifications

P-cadherin
Polyclonal
Unconjugated
CDH3
Cadherin 3, CDH3, CDHP, HJMD, PCAD, P-cadherin
Rabbit
Antigen Affinity Chromatography
RUO
1001, 116777, 12560
-20°C
Liquid
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
0.3 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P10287, P22223
CDH3
P-cadherin Fusion Protein Ag4758
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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