P-Glycoprotein Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA590029	100 μL

Catalog No. PIPA590029 Supplier Thermo Scientific Supplier No. PA590029

Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse brain; Cellular Location: Cell membrane, Multi-pass membrane protein Immunogen sequence: STVRNADVIA GFDDGVIVEK GNHDELMKEK GIYFKLVTMQ TAGNEVELEN AADESKSEID ALEMSSNDSR SSLIRKRSTR RSVRGSQAQD RKLSTKEALD

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Specifications

• Antigen: P-Glycoprotein
• Applications: Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Classification: Polyclonal
• Concentration: 1.61 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene: ABCB1
• Gene Accession No.: P06795, P08183, P21447
• Gene Alias: ABC superfamily, P-glycoprotein, ABC20, ABCB1, Abcb1a, Abcb1b, Abcb4, ATP binding cassette subfamily B member 1, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1), ATP-binding cassette sub-family B member 1, ATP-binding cassette sub-family B member 1A, ATP-binding cassette sub-family B member 1B, ATP-binding cassette transporter subfamily B, member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1), ATP-binding cassette, subfamily B (MDR/TAP), member 1A, ATP-binding cassette, sub-family B (MDR/TAP), member 1A, ATP-binding cassette, subfamily B (MDR/TAP), member 1B, ATP-binding cassette, sub-family B (MDR/TAP), member 1B, ATP-binding cassette, sub-family B (MDR/TAP), member 4, ATP-binding cassette, subfamily B, member 1A, ATP-binding cassette, subfamily B, member 1B, ATP-dependent translocase ABCB1, ATP-dependent translocase ABCB1, multidrug resistance protein 1, bovine p-glycoprotein, CD243, CLCS, colchicin sensitivity, doxorubicin resistance, ecotropic viral integration site 32, Evi32, GP170, mdr, Mdr1, MDR1A, Mdr1b, Mdr3, mdr-3, multi-drug resistance 3, multidrug resistance p-glycoprotein, multidrug resistance protein 1, Multidrug resistance protein 1A, multidrug resistance protein 1B, Multidrug resistance protein 2, multidrug resistance protein 3, multidrug resistance protein MDR1, multiple drug resistant 1a, P glycoprotein 1, P glycoprotein 3, P-glycoprotein, P-glycoprotein 1, P-glycoprotein 2, P-glycoprotein 3, P-glycoprotein/multidrug resistance 1, Pgp, p-gp, PGP1, PGP2, PGY1, Pgy-1, Pgy1-1, PGY2, Pgy3, Pgy-3, Phospholipid transporter ABCB1
• Gene Symbols: ABCB1, Abcb1a, Abcb1b
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 590-689 of human P Glycoprotein (NP_0009182)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 170913, 18669, 18671, 24646, 5243
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov