P-gp (CD243) Mouse, anti-Human, R718, Clone: 15D3, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752143

Catalog No. BDB752143

Description

The 15D3 monoclonal antibody specifically recognizes P-glycoprotein which is also known as CD243, ATP-binding cassette subfamily B member 1 (ABCB1) or Multidrug resistance protein 1 (MDR1). P-glycoprotein is a ∼170 kDa transmembrane glycoprotein protein that spans the membrane 12 times. P-glycoprotein acts as an ATP-dependent efflux pump for a large variety of drugs. It may be expressed at high levels by multidrug resistant (MDR) tumor cells. This efflux activity may lead to cellular resistance to the drugs used in chemotherapy. P-glycoprotein is present in many normal cell types including endothelial, epithelial, or secretory cells, and might protect them from naturally occurring xenobiotics.

Specifications

• Antigen: P-gp (CD243)
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: 15D3
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Form: Liquid